E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines.Like other selectins, it plays an important part in inflammation.In humans, E-selectin is encoded by the SELE gene.Aliases: SELE, CD62E, ELAM, ELAM1, ESEL, . In this context, the culture supernatants of cancer cells can trigger the expression of E- selectin by endothelial cells suggesting that cancer cells may release by themselves cytokines such as TNF-α, IL-1β or INF-γ that will directly activate endothelial cells to express E-selectin, P-selectin, ICAM-2 or VCAM.InterPro: IPR002396.
Feb 12, 2012 · Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell interactions with platelets, leukocytes, and soluble components significantly contribute to Cited by: 318. Major adhesion molecules that are involved in lung cancer spread include E-cadherin, intercellular adhesion molecule (ICAM)-1, and E-selectin. E-cadherin is a prime adhesion molecule on epithelial cells mediating cell adhesion in homotypic fashion. 17 x 17 KemLer, R.Cited by: 70.
Apr 28, 2015 · Shear-resistant adhesion and extravasation of disseminated cancer cells at the target organ is a crucial step in hematogenous metastasis. We found that the vascular adhesion molecule E-selectin preferentially promoted the shear-resistant adhesion and transendothelial migration of the estrogen receptor (ER) – /CD44 + hormone-independent breast cancer cells, but not of the ER + Cited by: 19. E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) play a role in cell adhesion to the vascular endothelium, and may have a role in tumour cell dissemination. Breast cancer cell lines induce the expression of E-selectin on vascular endothelium.Cited by: 167.
Shahina Ali, Jaswinder Kaur and Kamala D. Patel, Intercellular Cell Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, and Regulated on Activation Normal T Cell Expressed and Secreted Are Expressed by Human Breast Carcinoma Cells and Support Eosinophil Adhesion and Activation, The American Journal of Pathology, 157, 1, (313), (2000).Cited by: 161. Feb 15, 2014 · In breast cancer, the expression of The role of P- and L-selectin and its association in formation of the pre-metastatic niche is well known, but the functional contribution in the exact mechanism of metastasis is yet to discover. The cell-cell adhesion molecule E-cadherin.Cited by: 103.